2014
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Lee Daniels' The Butler
• British Academy of Film & Television Arts, Supporting Actress for Lee Daniels' The Butler
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for Lee Daniels' The Butler

2005
• Gullruten, Best Female Presenter for Nobels fredspris 2004

1998
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1997
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1996
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1995
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1994
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1993
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1992
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1991
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1989
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1988
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1987
• Emmy (Daytime), Outstanding Talk Show Host for The Oprah Winfrey Show

1986
• Academy Award, Actress in a Supporting Role
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture