2021
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless

2018
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Shameless
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Shameless
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless

2017
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Shameless
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless

2016
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Shameless
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless

2015
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Shameless
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Shameless

2014
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Shameless

2007
• Emmy (Primetime), Outstanding Lead Actor in a Miniseries or a Movie for Nightmares & Dreamscapes: From the Stories of Stephen King
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Bobby

2005
• Golden Globe, Best Performance by an Actor in a Limited Series or Motion Picture Made for Television for The Wool Cap
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Television Movie or Miniseries for The Wool Cap
• Emmy (Primetime), Outstanding Lead Actor in a Miniseries or a Movie for The Wool Cap

2004
• Golden Globe, Best Performance By an Actor in a Supporting Role in a Motion Picture for Seabiscuit
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Seabiscuit
• Emmy (Primetime), Outstanding Supporting Actor in a Miniseries or a Movie for Stealing Sinatra

2003
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Television Movie or Miniseries for Door to Door
• Emmy (Primetime), Outstanding Lead Actor in a Miniseries or a Movie for Door to Door
• Golden Globe, Best Performance by an Actor in a Limited Series or Motion Picture Made for Television for Door to Door

2000
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Magnolia
• Emmy (Primetime), Outstanding Lead Actor in a Miniseries or a Movie for A Slight Case of Murder

1998
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Boogie Nights

1997
• Academy Award, Actor in a Supporting Role for Fargo
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Supporting Role for Fargo