2019
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Grace and Frankie

2018
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Grace and Frankie
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Grace and Frankie

2017
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Grace and Frankie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Grace and Frankie

2016
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for Grandma
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Grace and Frankie
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Grace and Frankie

2015
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Grace and Frankie

2005
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing

2003
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing

1994
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for And the Band Played On

1985
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for All of Me

1978
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for The Late Show
• British Academy of Film & Television Arts, Actress for The Late Show

1976
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for Nashville
• British Academy of Film & Television Arts, Most Promising Newcomer to Leading Film Roles for Nashville
• Academy Award, Actress in a Supporting Role for Nashville

1972
• Golden Globe, Actress in a Supporting Role - Series or Television Movie for Rowan & Martin's Laugh-In