2023
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Ozark
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for Ozark
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Ozark

2022
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Ozark

2021
• Golden Globe, Best Television Actress - Drama Series for Ozark
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Ozark
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Ozark

2020
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Ozark

2019
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Ozark
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Ozark
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Ozark

2018
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Ozark

2013
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for The Big C: Hereafter

2012
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for The Big C

2011
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for The Big C
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for The Big C

2009
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for John Adams
• Golden Globe, Best Performance by an Actress in a Limited Series or Motion Picture Made for Television for John Adams

2008
• Academy Award, Actress in a Leading Role for The Savages
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for John Adams

2006
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for The Squid and the Whale

2005
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for Kinsey
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for Kinsey
• Academy Award, Actress in a Supporting Role for Kinsey

2004
• British Academy of Film & Television Arts, Actress in a Supporting Role for Mystic River
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Mystic River

2002
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Wild Iris

2001
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for You Can Count on Me
• Academy Award, Actress in a Leading Role for You Can Count on Me
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for You Can Count on Me