2017
• Emmy (Daytime), Outstanding Performer in an Animated Program for Trollhunters

2012
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for Boss

2004
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier

2003
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier

2002
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier

2001
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier

2000
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier

1999
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier

1998
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier

1997
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier

1996
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier

1995
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Comedy Series for Frasier
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier

1994
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Frasier
• Golden Globe, Best Performance by an Actor in a Television Series - Musical or Comedy for Frasier

1992
• Emmy (Primetime), Outstanding Lead Actor in a Comedy Series for Wings

1990
• Emmy (Primetime), Outstanding Supporting Actor in a Comedy Series for Cheers

1988
• Emmy (Primetime), Outstanding Supporting Actor in a Comedy Series for Cheers