2020
• Golden Globe, Best Actress in a Supporting Role in Any Motion Picture for Richard Jewell
• Academy Award, Actress in a Supporting Role for Richard Jewell

2016
• Emmy (Primetime), Outstanding Supporting Actress in a Limited Series or Movie for American Horror Story: Hotel

2015
• Golden Globe, Best Performance by An Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television for American Horror Story: Freak Show
• Emmy (Primetime), Outstanding Supporting Actress in a Limited Series or Movie for American Horror Story: Freak Show

2014
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for American Horror Story: Coven

2012
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Harry's Law
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Harry's Law
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Midnight in Paris

2011
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Harry's Law

2010
• Emmy (Primetime), Outstanding Supporting Actress for a Miniseries or Special for Alice

2006
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Ambulance Girl

2005
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Warm Springs

2003
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for About Schmidt
• Academy Award, Actress in a Supporting Role for About Schmidt
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for About Schmidt
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for My Sister's Keeper

2000
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Annie
• Golden Globe, Best Performance by an Actress in a Supporting Role in a Series, Limited Series or Motion Picture Made for Television for Annie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for Annie

1999
• British Academy of Film & Television Arts, Actress in a Supporting Role for Primary Colors
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for Primary Colors
• Academy Award, Actress in a Supporting Role for Primary Colors
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for Primary Colors

1998
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Titanic

1997
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for The Late Shift
• Golden Globe, Best Performance by an Actor in a Supporting Role in a Series, Limited Series or Motion Picture Made for Television for The Late Shift

1996
• Emmy (Primetime), Outstanding Supporting Actress for a Miniseries or Special for The Late Shift

1993
• British Academy of Film & Television Arts, Actress in a Supporting Role for Fried Green Tomatoes

1992
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for Fried Green Tomatoes

1991
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Misery
• Academy Award, Actress in a Leading Role for Misery