2022
• Academy Award, Actor in a Leading Role for Being the Ricardos
• Golden Globe, Best Performance By an Actor in a Motion Picture - Drama for Being the Ricardos
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Leading Role for Being the Ricardos

2021
• Los Premios Goya, Best Leading Actor for El buen patrón

2019
• Los Premios Goya, Best Leading Actor for Todos lo saben

2018
• Los Premios Goya, Best Leading Actor for Loving Pablo

2013
• British Academy of Film & Television Arts, Supporting Actor for Skyfall
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Supporting Role for Skyfall

2011
• Academy Award, Actor in a Leading Role for Biutiful
• Los Premios Goya, Best Leading Actor for Biutiful
• British Academy of Film & Television Arts, Leading Actor for Biutiful

2010
• Cannes Film Festival, Best Actor for Biutiful

2009
• Golden Globe, Best Performance By an Actor in a Motion Picture - Musical or Comedy for Vicky Cristina Barcelona

2008
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for No Country for Old Men
• Golden Globe, Best Performance By an Actor in a Supporting Role in a Motion Picture for No Country for Old Men
• British Academy of Film & Television Arts, Supporting Actor for No Country for Old Men
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Supporting Role for No Country for Old Men
• Academy Award, Actor in a Supporting Role for No Country for Old Men

2005
• Los Premios Goya, Best Leading Actor for Mar adentro
• Golden Globe, Best Performance By an Actor in a Motion Picture - Drama for Mar adentro

2004
• Mostra del Cinema di Venezia, Volpi cup for the best male performance for Mar adentro

2003
• Festival de Cinema de Gramado, Best Actor - Foreign Movie for Los lunes al sol
• Los Premios Goya, Best Leading Actor for Los lunes al sol

2001
• Academy Award, Actor in a Leading Role for Before Night Falls
• Golden Globe, Best Performance By an Actor in a Motion Picture - Drama for Before Night Falls

1998
• Los Premios Goya, Best Leading Actor for Live Flesh

1996
• Los Premios Goya, Best Leading Actor for Boca a boca

1995
• Los Premios Goya, Best Supporting Actor for Días contados

1994
• Los Premios Goya, Best Leading Actor for Huevos de oro

1993
• Los Premios Goya, Best Leading Actor for Jamón, jamón