2021
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for Hillbilly Elegy
• Academy Award, Actress in a Supporting Role for Hillbilly Elegy
• Golden Globe, Best Supporting Actress - Motion Picture for Hillbilly Elegy

2019
• Academy Award, Actress in a Leading Role for The Wife
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for The Wife
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for The Wife
• British Academy of Film & Television Arts, Leading Actress for The Wife

2013
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for Damages

2012
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for Albert Nobbs
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Albert Nobbs
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Damages
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Damages
• Academy Award, Actress in a Leading Role for Albert Nobbs

2011
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Damages

2010
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Damages
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Damages
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for Damages

2009
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Damages

2008
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Damages
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Damages
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for Damages

2006
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Shield

2005
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for The Lion in Winter
• Golden Globe, Best Performance by an Actress in a Limited Series or Motion Picture Made for Television for The Lion in Winter
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Shield

2004
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for The Lion in Winter

1998
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for In the Gloaming

1997
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for 101 Dalmatians
• Emmy (Primetime), Outstanding Lead Actress for a Miniseries or Special for In the Gloaming

1996
• Golden Globe, Best Performance by an Actress in a Limited Series or Motion Picture Made for Television for Serving in Silence: The Margarethe Cammermeyer Story
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for Serving in Silence: The Margarethe Cammermeyer Story

1995
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Serving in Silence: The Margarethe Cammermeyer Story

1993
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Skylark

1992
• Golden Globe, Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for Sarah, Plain and Tall

1991
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Sarah, Plain and Tall

1989
• Academy Award, Actress in a Leading Role for Dangerous Liaisons
• British Academy of Film & Television Arts, Actress in a Leading Role for Dangerous Liaisons

1988
• Academy Award, Actress in a Leading Role for Fatal Attraction
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Fatal Attraction

1986
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for Maxie

1985
• Golden Globe, Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for Something About Amelia
• Academy Award, Actress in a Supporting Role for The Natural

1984
• Academy Award, Actress in a Supporting Role for The Big Chill
• Emmy (Primetime), Outstanding Lead Actress in a Limited Series or Special for Something About Amelia

1983
• Academy Award, Actress in a Supporting Role for The World According to Garp