2022
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Handmaid's Tale
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Handmaid's Tale

2021
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Handmaid's Tale

2020
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Handmaid's Tale
• Australian Academy of Cinema and Television Arts Awards, Best Lead Actress for The Invisible Man

2019
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Handmaid's Tale

2018
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Handmaid's Tale
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Handmaid's Tale
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Handmaid's Tale
• Logie Awards, Most Outstanding Actress for Top of the Lake: China Girl

2017
• Australian Academy of Cinema and Television Arts Awards, Best Lead Actress - Drama for Top of the Lake: China Girl
• Australian Academy of Cinema and Television Arts Awards, Best Lead Actress - Drama for Top of the Lake
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Handmaid's Tale

2016
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men

2015
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Mad Men

2014
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for Top of the Lake
• Golden Globe, Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for Top of the Lake

2013
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Mad Men

2012
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Mad Men

2011
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for Mad Men
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Mad Men
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Mad Men
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men

2010
• Emmy (Primetime), Outstanding Supporting Actress in a Drama Series for Mad Men
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men

2009
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for Mad Men
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for Mad Men
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men

2008
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for Mad Men