2018
• Emmy (Primetime), Outstanding Lead Actress in a Limited Series or Movie for Law & Order True Crime: The Menendez Murders

2016
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie

2015
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Nurse Jackie

2014
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Nurse Jackie

2013
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Nurse Jackie

2012
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie

2011
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Nurse Jackie

2010
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Nurse Jackie
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Nurse Jackie
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Nurse Jackie

2008
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos

2007
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos

2005
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos

2004
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos

2003
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos

2002
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos

2001
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos

2000
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The Sopranos
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The Sopranos

1999
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The Sopranos