2021
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mom

2020
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Bombshell

2018
• Academy Award, Actress in a Supporting Role for I, Tonya
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for I, Tonya
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mom
• British Academy of Film & Television Arts, Supporting Actress for I, Tonya
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for I, Tonya

2017
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mom

2016
• Emmy (Primetime), Outstanding Supporting Actress in a Comedy Series for Mom

2015
• Golden Globe, Best Performance by an Actress in a Supporting Role in a Series, Limited Series or Motion Picture Made for Television for Mom
• Emmy (Primetime), Outstanding Supporting Actress in a Comedy Series for Mom

2014
• Emmy (Primetime), Outstanding Supporting Actress in a Comedy Series for Mom

2012
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for The Help

2008
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Hairspray

2006
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing

2005
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing

2004
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The West Wing
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing

2003
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for The Hours
• Golden Globe, Best Performance by an Actress in a Television Series - Drama for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing

2002
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing
• Emmy (Primetime), Outstanding Lead Actress in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing
• Golden Globe, Best Performance by An Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television for The West Wing

2001
• Golden Globe, Best Performance by An Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television for The West Wing
• Emmy (Primetime), Outstanding Supporting Actress in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing

2000
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for American Beauty
• Emmy (Primetime), Outstanding Supporting Actress in a Drama Series for The West Wing