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A mysterious, fast-acting and extremely deadly virus triggers an emergency lockdown on the 6th floor of Westside Hospital; in an effort to save a crashing Richard from a deadly virus, Amy gets infected with it.

Happy Birthday

Stuck

On Michael's first day as Chief of Internal Medicine, Joan arrives at the hospital as a patient in dire straits; Amy clashes repeatedly with Richard over Joan's treatment plan; Gina makes a nearly impossible medical decision for a young patient.

The Big Chair

On her last day at Westside, Joan chooses an unlikely successor, crowns a Chief Resident and imparts some final wisdom to the next generation; Gina steps in to help TJ's patient; Amy and Jake's tension intensifies while treating a pregnant teen.

Orientation

After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness; Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries.

Good Hands

Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker; Sonya and TJ enlist Jake's help with the delicate Joan situation; Amy and TJ take on the case of a medical malpractice lawyer.

The Best We Can Do

While navigating the fallout from Katie's secret, Amy treats a critically ill patient with a dark one of her own; Jake is forced to hide the truth from Amy about Rachel's health scare; Richard returns with a trick up his sleeve.

Trust

A shocking turn of events ensues when Amy and Jake treat an expectant mother injured during a robbery; Michael is challenged to open up when Katie's therapist invites him and Amy to a session; TJ and Sonya help Julie navigate a mysterious illness and an unexpected romance.

When You Know, You Know

The race for chief resident intensifies as Joan tasks Amy and Sonya with evaluating each other's case work; Amy tends to a politician with a disability whose dire health complications threaten to interrupt a crucial vote.

Fare Well

Charlie fights for his life at Westside with Hannah by his side; a familiar face returns to Westside and Amy is not happy about it.

Inquisition

The search for Amy's hacker intensifies when the hospital finally brings in the FBI; Hannah, devastated by the death of her patient, works with Amy to treat a sick older man whose daughter believes has been poisoned.

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After a brain injury erases the last eight years of Dr. Amy Larsen's life, she must navigate an unfamiliar world where she has no recollection of patients she's treated or the tragedy that caused her to push everyone away.

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Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.

S2 E1 | Her Heart