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A seemingly random murder outside UHOP sets the stage for the arrival of someone from Watson and Sherlock Holmes' past.

Watson

The Cobalt Fissure

As Adam's wife goes in for a C-section to deliver triplets, chaos ensues when their OB-GYN passes out in the operating room; a severe storm detours Watson and Mary's trip to find a renowned doctor to remove Watson's brain tumor.

The Rule of Three

Following his brain tumor diagnosis, Watson goes on medical leave to seek treatment; a notorious South American dictator demands Watson see to his mysterious autoimmune condition personally.

Sic Semper Tyrannis

Watson and Laila lie injured and awaiting rescue as the team races to find them before it's too late; in a state between life and death, Watson's mind plays out a modern-day investigation of a case that has long haunted him.

Unsolved Mysteries

Watson investigates a case involving a mentally unstable mother, with the woman's delusions serving as a mirror to his own newly discovered hallucinations.

Respect the Process. Respect the Quirks.

Watson and the fellows race to save the life of a young woman who needs a lifesaving kidney donation; Sherlock returns to help crack unsolved cases in Pittsburgh.

A Third Act Surprise

Watson is sued by a long-term patient suffering from a disorder that affects multiple body systems.

Wrongful Life

Watson and the fellows fight to revive a 30-year-old woman after her heart inexplicably stops repeatedly.

For a Limited Time Only

When a patient arrives plagued by a mysterious neurological disorder, Watson and the fellows discover they were forced to eat their parents amid a childhood survival incident; Adam is struggling with how his future will change as a father.

A Family Meal

Watson and the fellows race against the clock to save a man and his pregnant wife from a terrifying sinkhole; Ingrid's future with her therapy group becomes unclear.

The Tunnel Under the Elms

Watson's biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong; Watson becomes suspicious of Sherlock.

Never Been CRISPR'd

Watson and the fellows help Laila's son Micah, who was injured in a car accident while pursuing his crush.

Shannon Says Bex Loves Micah

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Six months after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson turns his attention from solving crimes to solving medical mysteries.

S2 E20 | The Cobalt Fissure