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Watson's biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong; Watson becomes suspicious of Sherlock.

Watson

Never Been CRISPR'd

Watson and the fellows help Laila's son Micah, who was injured in a car accident while pursuing his crush.

Shannon Says Bex Loves Micah

Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter's illness.

Livvy Sees the Doctor

Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts.

Giant Steps

Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer; Mycroft Holmes lets Watson know his team's work at UHOP may no longer have funding available.

Buying Time

While visiting another hospital, Watson becomes convinced that a man is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade; Sherlock is back in town and is staying with Watson.

Lucky

Watson and the team jump into action when four people become infected with a flesh-eating bacterium; Shinwell searches for meaning as a nursing student; Adam's wedding to Lauren risks being halted.

Happy When It Rains

Watson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10.

Expletive Deleted

When a microbiology university researcher returns from an expedition to Siberia, she and her team members fall ill from a possible revived pathogen; Watson catches up with his friend Sherlock Holmes after finding out he is alive.

Back From the Dead

Watson and the fellows spring back into action when Mary's mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed; Sherlock Holmes resurfaces after being presumed dead.

A Son in the Oven

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Six months after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson turns his attention from solving crimes to solving medical mysteries.

S2 E10 | Never Been CRISPR'd

E10 | Never Been CRISPR'd

E9 | Shannon Says Bex Loves Micah

E8 | Livvy Sees the Doctor

E7 | Giant Steps

E6 | Buying Time

E5 | Lucky

E4 | Happy When It Rains

E3 | Expletive Deleted

E2 | Back From the Dead

E1 | A Son in the Oven