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In Brazil, Claudio lives with a condition that bent his head backward; ahead of his 50th birthday, he wants to climb a sacred mountain; in Norway, Birgitte lives with a different presentation of the same condition; she's training for the next Paralympics.

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Upside Down With a Twist

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Life defined by height: in Turkey, the world's tallest woman lives with an unknown genetic condition linked to extreme growth and fragile bones, while in Brazil, the world's shortest couple navigate dwarfism and its physical challenges.

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Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured; with 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

Ugliest Man

Mark's hands are 20 times bigger than a normal adult male's; after learning that his condition may require amputation, Mark stopped seeing doctors; now troubling changes to his hands means he must go back. If not for himself, then for his young daughter.

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Following people from around the globe living with rare and remarkable physical conditions.

S1 E4 | Upside Down With a Twist