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Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions; Mahfuza prepares for her first boxing match; Nelly fully supports her friend but worries that the high risks may outweigh the rewards.

Most Extreme Humans

Skin in the Game

Summer has macromastia, a condition that causes her breasts to keep growing. With constant pain in her back and neck from breasts that are now a third of her overall body weight, Summer travels from Scotland to Los Angeles looking for answers.

Keep Calm and Girdle On

In rural Indian, Lalit's face and body have been thickly covered in hair since the day he was born. Doctors theorized that the hair would fall out once he reached peak maturity. Now that he's turning 20, Lalit seeks out a specialist to learn his fate.

Hair Today, Gone Tomorrow?

Milagros lives with tumors so heavy that her face droops down to her torso; after hiding away, a health scare is forcing her out into the world; twenty-one-year-old Lizzie is preparing to live independently even after tumors have grown over her eyes.

Face to Face

In Brazil, Claudio lives with a condition that bent his head backward; ahead of his 50th birthday, he wants to climb a sacred mountain; in Norway, Birgitte lives with a different presentation of the same condition; she's training for the next Paralympics.

Upside Down With a Twist

Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured; with 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

Ugliest Man

Mark's hands are 20 times bigger than a normal adult male's; after learning that his condition may require amputation, Mark stopped seeing doctors; now troubling changes to his hands mean he must go back. If not for himself, then for his young daughter.

Biggest Hands

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Following people from around the globe living with rare and remarkable physical conditions.

S1 E7 | Keep Calm and Girdle On