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Sam Foster (Ewan McGregor), a psychiatrist, has a new patient, Henry Letham (Ryan Gosling), who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist (Janeane Garofalo) and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.