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Crime Central

Detectives search for an elderly woman who vanished after returning from a doctor's appointment, with the suspicion that the use of pain medication may have contributed to her disappearance.

The First 48: Missing Persons

The Good Mother

A man reports that his missing girlfriend left him an ominous phone call; a Chicago teenager falls under the influence of a gang member considered to be armed and dangerous.

3:10 to Yuma; Harm's Way

Police detectives investigate the subculture of Chicago's black gay males when a young man leaves a disturbing voice mail message and then goes missing.

Family Matters

A woman reports her husband missing the day after their second wedding anniversary; a missing hotel guest is spotted on surveillance video leaving the establishment.

Lost Anniversary; Checked Out

An online predator may be behind the disappearance of an aspiring model; police race to locate a mentally disabled man before he becomes a victim of street violence.

Deleted; Cruel Streets

Detectives probing a dental student's disappearance turn their focus on the victim's husband and mother, but the investigation stalls after both pass their polygraph tests.

In the Wind

A missing mother of four leaves behind a suicide note; a detective searches for a disoriented woman wandering the streets of Chicago.

Desperate Measures; The Big City

Police suspect that one man may be responsible for the disappearances of two women and their young children.

A History of Violence

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When a person goes missing, the first 48 hours are the most crucial in an investigation.

S2 E5 | Lost Anniversary; Checked Out