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Tamy faces a tough choice when her husband wants her back, but only if she moves away from Houston and Dr. Now's program; Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

My 600-Lb. Life: Where Are They Now?

Tamy & Karina

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey; June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

June, Chad & Pauline

For Milla Clark, after three years and five surgeries, success would mean beating the odds and becoming one of Dr. Nowzaradan's most impressive weight-loss patients, but failure would mean slipping back to the bedbound life.

Milla

Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress; if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.

Jennifer, Marissa & Liz

In the fourth year of his weight-loss journey, Sean struggles to get past the loss of his mother and live on his own; Dr. Now intervenes to control Sean's eating for a time.

Sean

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Lee, Rena & Sarah

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Janine

As Steven heals from his weight loss surgery, his brother Justin finally decides to come to Texas to get the same procedure, but his feelings toward Steven immediately begin to sabotage his hopes of surgery.

The Assanti Brothers

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Follows the struggles of overweight people as they try to shed the pounds, and how they feel about their weight loss progress.

S5 E4 | Sean

E8 | Tamy & Karina

E7 | June, Chad & Pauline

E6 | Milla

E5 | Jennifer, Marissa & Liz

E4 | Sean

E3 | Lee, Rena & Sarah

E2 | Janine

E1 | The Assanti Brothers