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Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic; as everyone either moves on or falls away, Bill and Virginia find solace in one another.

Masters of Sex

A Private Affair

Masters and Johnson return from Topeka, each grappling with the trip's ramifications; Art and Nancy look to tie up loose ends to have a fresh start; Libby embarks on a road trip with Bram that changes her perspective.

Night and Day

Masters and Johnson pose as a couple to investigate a competing clinic; Art, Nancy and Langham take advantage of Bill and Virginia's absence.

Topeka

Masters wants to groom Art as his protege in a new area of research; Johnson keeps Nancy at arm's length; Betty asks for help.

In to Me You See

Virginia wants to get her relationship with Bill back on track; Bill tries to find satisfaction elsewhere; Betty and Helen prepare for a new addition; Art and Nancy discuss consequences.

Family Only

Masters and Johnson's troubles come to a head when the trial begins; Virginia tries to revive their career; Bill faces the reality of charges.

Outliers

Johnson, Masters, Libby and Keller end up at a party together; pairings and perspectives change throughout the night.

Coats or Keys

Masters and Johnson adjust to their new partners, but second-guess their instincts to remain apart; Libby embraces life as a newly-single woman.

The Pleasure Protocol

Masters and Johnson seek new partners to help put the past behind them; Libby reevaluates her relationship with Bill and Virginia.

Inventory

Masters and Johnson try to find purpose with out each other; Libby is alone for the first time since her marriage.

Freefall

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Scientists William Masters and Virginia Johnson were pioneers of the study of human sexuality.

S4 E1 | Freefall

E10 | A Private Affair

E9 | Night and Day

E8 | Topeka

E7 | In to Me You See

E6 | Family Only

E5 | Outliers

E4 | Coats or Keys

E3 | The Pleasure Protocol

E2 | Inventory

E1 | Freefall