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Carter and Abby treat two children whose symptoms suggest a deadly disease and force the hospital to lock down in quarantine until federal experts can arrive.

Lockdown

Dr. Greene takes his daughter Rachel to Hawaii in the hopes of patching up their troubled relationship.

On the Beach

Dr. Carter reads a letter from ailing Dr. Greene to the emergency-room staff; Dr. Weaver lashes out at a mentally challenged patient; a terminally ill, homeless man continues asking for Greene's help.

The Letter

When Dr. Lewis gets a distressing phone call from her niece, she races to New York to search for the child and her troubled sister.

Brothers & Sisters

When Greene's aggressive illness begins affecting his coordination, he wonders if his fate will mirror those of his terminally ill patients.

Orion in the Sky

Corday and Greene awkwardly cross paths in the ER; Weaver treats victims of an inferno which may cost the life of a dear friend.

Bygones

After a dominatrix makes an appearance in the ER, Dr. Weaver orders the staff to attend a sexual-harassment seminar, where truths surface about their relationships.

Secrets and Lies

Greene fights loneliness and pain by throwing himself into his work; Chen discovers that a comatose teenager is pregnant and ready to give birth.

It's All in Your Head

Greene confronts Corday when she orders Rachel out of their home; Abby tries to protect a battered neighbor who refuses to press charges against her husband.

A Simple Twist of Fate

An accidental overdose brings Drs. Greene and Corday's baby into the emergency room, gripping the parents with fear.

Damage Is Done

An injured and condemned murderer (Cyril O'Reilly) wants to die in the ER rather than await execution; Abby advises a neighbor (Christina Hendricks) to seek shelter from her abusive husband (Matthew Settle).

A River in Egypt

Abby helps a distraught boy whose mother died of a stroke; a man with schizophrenia who once stabbed Carter and killed a doctor checks into the ER.

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Doctors deal with personal and professional crises as they labor to save lives in the emergency room at County General Hospital in Chicago.

S8 E22 | Lockdown