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Dr. Lee expresses appreciation to her friend Dr. Kristen Townley for supporting her post-stroke and in life; Matline has a passion for horseback riding, but a painful bump on her back could end her time in the saddle; actress, comedian and podcaster Steph Tolev is concerned about a head bump that could have a big impact on her appearance; Dr. Hannah Tolson takes a break from residency to join Dr. Lee and meet Annie, who has a rare genetic condition that causes bumps on her face and scalp.

Dr. Pimple Popper: Breaking Out

'Til Next Time, Partner

Tom is a charismatic homesteader whose increasingly large, bulbous nose is obstructing his breathing and threatening his family's livelihood; Dr. Lyndsey meets her biggest challenge; she and Dr. Lee try to help hairstylist Kamaria with a neck bump.

That's Not the Nose I Recognize!

Charming Justin feels the thousands of bumps covering his face and body ruin his chance to find love; reclusive Gene's girlfriend is frustrated that he will only leave the house to watch trains due to the gigantic lump on his head.

Looking for Love

Sevyn Streeter visits Dr. Lee with her friend Rose, who is concerned that an unsightly shoulder lump is ruining her modeling career; Jamie is a family man who fears his young daughter is growing something that matches his angry, huge neck growth.

Pop Star

Craig fears the massive growth on his neck could prevent him from helping his sick mother; Gwen is covered in dry, itchy patches that are causing hair loss and devastating her confidence.

Hiding Behind a Wig

Dr. Lee is ready to take the lead on her first surgery since her stroke, with Dr. Townley now assisting; Quentin has a cantaloupe-sized bump on his tricep that is ruining his mechanic career and making his girlfriend miserable.

Hand Me That Scalpel!

John is a sweet guy trying to get over his bumpy past; Tami has yellow deposits on her eyelids that make it impossible for her to feel beautiful; Dr. Farhang helps Dr. Lee with a terrified patient, Lili, who has a lump on the back of her arm.

Gone in CYST-Y Seconds

Angela has a big, melon-sized growth on the back of her neck that she fears can ruin her daughter's wedding; Loretta is terrified that her painful can get in the way of making her movie.

A Mother's Lump

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Dr. Sandra Lee, also known as Dr. Pimple Popper, is ready to take her practice to the next level. Dr. Lee will be providing intimate self-shot footage of her life outside the office.

S2 E16 | Hiding Behind a Wig