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While the Perrios struggle with weight loss, the revelation of a past tragedy explains their resistance to recovery; the siblings must come together to overcome their fears and forge a path to a healthy future.

My 600-Lb. Life

One Ton Family, Part 2

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

One Ton Family, Part 1

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Jennifer & Marissa's Story

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Schenee's Story

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Sarah's Story

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Renee's Story

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Benji & David's Story

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Tamy Lyn's Story

With the support of his fiancée, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

Robert's Story

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight, or she will never see her grandchildren grow up.

Lisa's Story

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Karina's Story

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Liz's Story

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After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

S6 E1 | Rena & Lee's Story