- Saturday Night Live
TV-14 | Comedy
- Stumble
TV-14 | Comedy
- The Suplex Duplex Complex
TV-14 | Comedy/Special
- Sincerely, Camille
TV-14 | Comedy/Animated
- Scare Tactics
TV-14 | Reality/Comedy
- SNL Vintage
TV-14 | Comedy
- Servant of the People
TV-14 | Comedy/Sitcom
- Stupid Pet Tricks
TV-14 | Comedy/Variety
- Suits
TV-14 | Crime drama/Comedy
- Stand Up & Deliver
TV-14 | Comedy
- Sinbad: Make Me Wanna Holla
TV-14 | Comedy/Documentary
- Sealab 2021
TV-14 | Comedy/Animated
- Smart Pipe
TV-14 | Comedy/Special
- Squidbillies
TV-14 | Comedy/Animated
- Space Ghost: Coast to Coast
TV-14 | Talk/Comedy
- School of Champions
NR | Comedy/Drama
- Spinal Destination
NR | Comedy
- Summer Shortstacular with Big City Greens
NR | Comedy/Adventure
- Spinal Tap II: The End Continues: Extras
NR | Comedy
- Sando
NR | Comedy
- Stand Up for the Pits Comedy Special with Rebecca Corry Hosted by Kayley Cuoco
NR | Comedy/Special
- Sarah Squirm: Live + in the Flesh
NR | Comedy/Special
- Send Help
NR | Comedy
- Stars of Space Jam
NR | Comedy/Animated
- Sam Tallent: Waiting for Death to Claim Us
NR | Comedy/Special
- Sinbad: Where U Been?
NR | Comedy/Documentary
- Sábados felices
NR | Comedy/Entertainment
- Señor, dame paciencia
NR | Comedy
- ¡Solo se vive dos veces!
NR | Comedy/Drama
- Spring Shorts-tacular with The Ghost and Molly McGee
NR | Comedy/Adventure
- Sitcom
NR | Comedy
- Salt & Light
NR | Comedy/Religious
- Simón dice
NR | Comedy
- Somos tú y yo
NR | Comedy/Music