2006
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Bobby
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for The Departed

2004
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Drama Series for The West Wing
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing

2003
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Drama Series for The West Wing
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for The West Wing

2002
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Drama Series for The West Wing
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing

2001
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Drama Series for The West Wing
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for The West Wing

2000
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for The West Wing
• Emmy (Primetime), Outstanding Lead Actor in a Drama Series for The West Wing
• Screen Actors Guild Awards, Outstanding Performance by a Male Actor in a Drama Series for The West Wing

1984
• Golden Globe, Best Performance by an Actor in a Miniseries or Motion Picture Made for Television for Kennedy

1980
• Golden Globe, Best Performance by an Actor in a Television Series - Drama for Blind Ambition

1979
• British Academy of Film & Television Arts, Actor for Apocalypse Now

1968
• Golden Globe, Best Performance By an Actor in a Supporting Role in a Motion Picture for The Subject Was Roses