2013
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Supporting Role for The Sessions
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for The Sessions
• British Academy of Film & Television Arts, Supporting Actress for The Sessions

2012
• Academy Award, Actress in a Supporting Role for The Sessions

2007
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for Bobby

1999
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You

1998
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for As Good as It Gets
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for As Good as It Gets
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Mad About You

1997
• Academy Award, Actress in a Leading Role for As Good as It Gets
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Mad About You
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You

1996
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Mad About You

1995
• Screen Actors Guild Awards, Outstanding Performance by an Ensemble in a Comedy Series for Mad About You
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Comedy Series for Mad About You

1994
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You

1993
• Golden Globe, Best Performance by an Actress in a Television Series - Musical or Comedy for Mad About You
• Emmy (Primetime), Outstanding Lead Actress in a Comedy Series for Mad About You