2008
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for What if God Were the Sun?

2007
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for What if God Were the Sun?

2003
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Hysterical Blindness
• Golden Globe, Best Performance by an Actress in a Supporting Role in a Series, Limited Series or Motion Picture Made for Television for Hysterical Blindness

2002
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Wild Iris

2000
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for The Color of Love: Jacey's Story

1997
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for Unhook the Stars

1993
• Golden Globe, Best Performance by An Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television for Crazy in Love

1992
• Emmy (Primetime), Outstanding Lead Actress in a Miniseries or Movie for Face of a Stranger

1988
• Golden Globe, Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for The Betty Ford Story

1987
• Emmy (Primetime), Outstanding Lead Actress for a Miniseries or Special for The Betty Ford Story

1986
• Golden Globe, Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for An Early Frost
• Emmy (Primetime), Outstanding Lead Actress for a Miniseries or Special for An Early Frost

1984
• Golden Globe, Best Performance by an Actress in a Limited Series or Motion Picture Made for Television for Thursday's Child

1981
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Gloria
• Academy Award, Actress in a Leading Role for Gloria

1978
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Opening Night

1975
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for A Woman Under the Influence
• Academy Award, Actress for A Woman Under the Influence