2015
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for Flowers in the Attic

2014
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Flowers in the Attic

2013
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Political Animals

2008
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Television Movie or Miniseries for For One More Day

2006
• Emmy (Primetime), Outstanding Supporting Actress in a Miniseries or a Movie for Mrs. Harris

2001
• Screen Actors Guild Awards, Outstanding Performance by a Female Actor in a Leading Role for Requiem for a Dream
• Academy Award, Actress in a Leading Role for Requiem for a Dream
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Requiem for a Dream

1996
• Screen Actors Guild Awards, Outstanding Performance by a Cast in a Motion Picture for How to Make an American Quilt

1987
• Emmy (Primetime), Outstanding Lead Actress for a Miniseries or Special for Pack of Lies

1982
• Golden Globe, Best Performance by an Actress in a Limited Series or Motion Picture Made for Television for The People vs. Jean Harris

1981
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Resurrection
• Emmy (Primetime), Outstanding Lead Actress in a Limited Series or Special for The People vs. Jean Harris
• Academy Award, Actress in a Leading Role for Resurrection

1979
• Golden Globe, Best Performance By an Actress in a Motion Picture - Musical or Comedy for Same Time, Next Year
• Academy Award, Actress in a Leading Role for Same Time, Next Year

1976
• British Academy of Film & Television Arts, Actress for Alice Doesn't Live Here Anymore

1975
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for Alice Doesn't Live Here Anymore
• Academy Award, Actress for Alice Doesn't Live Here Anymore

1974
• Academy Award, Actress for The Exorcist
• Golden Globe, Best Performance By an Actress in a Motion Picture - Drama for The Exorcist

1972
• Golden Globe, Best Performance By an Actress in a Supporting Role in a Motion Picture for The Last Picture Show
• Academy Award, Actress in a Supporting Role for The Last Picture Show