Not a "message movie" in the least (far more about goofy, over-the-top humor), but good guys do prevail, and crimes like drug smuggling are portrayed negatively.
Over-the-top/exaggerated violence played for laughs, including people being shot, dead bodies being hurled at moving cars, fights, and people being menaced with a lumber saw.
Pervasive sex talk, especially jokes about extreme sex acts. Partial nudity, including bare butts and topless women at a brothel. A man is shown naked (including views of what's most likely a prosthetic penis, which is interacted with for laughs). Descriptions of genitalia; comical views of intercourse, without nudity.
Extreme, constantly used profanity and graphic sexual language. Words heard include "f--k," "motherf----r," "s--t," "bitch," "d--k," "c--k," "p---y," "pr--k," "t-ts," "a--hole," "crap," "damn," etc. Also many descriptions of sex acts.
Drinking, Drugs & Smoking
Many drug references, and lots of drug use shown on-screen. Smoking pot. Abuse of illegal pills is a running gag that's played for laughs.