Despite all the misadventures and crazy shenanigans, Greg realizes that his family is important, and he loves them. The family shows perseverance to get to Meemaw's house in time. The brothers demonstrate teamwork, but it's in the service of lying to their parents.
Chase scenes end in a car accident that happens when some of the family members have taken off their seatbelts. There's a loud noise that Rodrick thinks is a gunshot. Greg is cornered in a bathtub by the man who's been chasing him -- it's set up to look like the shower scene from Psycho. Greg and Rodrick lie and sneak off in an Uber to a gaming convention an hour away. Greg ends up in a runaway boat. The family stays in a hotel infested with roaches. Also gross-out moments with bodily functions (barf, bowel movements, etc.).
One of the kids finds a bra in a suitcase. Rodrick tries to impress girls.
Mostly insult language like "stupid," "fat," "weirdo," and "loser." One use of "hell" and several uses of "oh my god."
Various brands are seen throughout the movie, including Graco, Coach, X-box, and New Balance. The boys talk about taking an Uber.