Perseverance and compassion are major themes. No matter how grave the diagnosis that Hawking receives, he doesn't let it get in the way of what he wants to do with his life and work, thanks in large part to his supportive wife, Jane, who makes sure he has everything he needs.
At one point Hawking suffers what looks to be a pretty painful fall and is shown suffering through his illness.
Some kissing and frank discussion of Hawking's sexuality in the face of a motor-neuron disease. In one scene, he's shown paging through a Penthouse magazine with the help of a female assistant.