While the takeaway is that life is too short for passing judgements, holding grudges, and not reaching out for your dreams, these messages are mixed in with plenty of drug use, swearing, and juvenile behavior (by adults).
Positive Role Models & Representations
A few mildly violent moments, but all played for laughs, including: an old man aggressively poking a relative with a cane and constantly berating him; two brothers who regress and start wrestling each other because they're upset with each other; former lovers arguing loudly; a guest at the funeral accidentally drugged and thrown around.
Sexual innuendos fly; a guest shows compromising pictures of him and a lover (the audience doesn't see anything explicit, but the reaction from the characters imply that one of the pics is); references to a sexual position; a character strips while he is on drugs; another character discusses how she needs to be intimate with her husband to get pregnant; an older man hits on a younger woman.
Frequently pungent: everything from "moron" to "bastard" to "damn," and "s--t," "asshole," and "f--k." Also, several uses of "Goddamn," "Oh my God," and "Jesus Christ" as exclamations.
A few brands name-checked, including TMZ and Valium.
Ease of Play
A pharmacology student hides his stash of homemade pills made from mescaline and LSD into a bottle labeled "Valium," which is then mistaken for the name on the bottle and is ingested by at least two of the characters, causing mayhem.