Despite the relentlessly depressing, gruesome subject matter and millions (billions?) of deaths, the film's main point is that family is ultimately the most important thing in life. Several characters risk their lives or well-being for family members, and one character tries (tragically) to contact his family too late. Certain selfish characters are redeemed by saving family members, and the movie makes a point of mentioning that the most selfish character of all has no family. Aside from that, a few characters look beyond family to try to rescue total strangers as well.
Not much blood and gore (one character gets his leg gouged in a giant gear), but the massive destruction results in countless anonymous deaths. The movie does focus dramatically on certain known faces as they meet their terrible fates, but it rarely stops to linger on them. Two children watch as their father falls to his death and another character is ground up in some machinery. Smaller moments of hostility at a boxing match, and a character punches another character in the face. A mass suicide is mentioned on a news report.
One character is a plastic surgeon who does breast implants. He meets one of his patients, and they mention her surgery several times. Gordon and Kate briefly discuss "making a baby" of their own. Kate and Jackson kiss once, and there's a near-kiss between Adrien and the president's daughter.
Fairly light use of strong language, although there's at least one "f--k," a few uses of "s--t," and other words like "damn," "ass," "hell," "goddamn," and "oh my God." One character flips another one off.
A wealthy character brags about his fancy new Bentley. Pull-Ups diapers are discussed and shown.
Two minor adult characters are shown drinking. One takes his first drink in 25 years when he discovers that the world is going to end.