All of the characters are flawed, though most of them have good intentions at heart. Kate frequently comes across as judgmental and a little bit snobby, while Angie's irresponsible "white trash" background is played up for laughs -- though, to the movie's credit, she has more depth than similar characters in other films. Characters deceive each other, attempt blackmail, and more. A subplot involves a big corporation coming into a small neighborhood and possibly hurting local business. New age philosophies are mocked (mostly gently). All but one of the central cast members are Caucasian.
Two women hurl insults at each other during a massive screaming argument. A little bit of slapstick physical comedy.
No nudity, and not much beyond kissing is shown. But there are some crass references to baby-making, including a shot in which Poehler's character spreads her legs for artificial insemination. Words like "horny" are used. A couple spends the night together after a first date.
Language includes "damn," "a--hole," a handful of "s--t"s, and one "effin" as a stand-in for "f--k." Some name-calling.
Product placements galore, including Luna Bars, Dr. Pepper, Tastykakes, Red Bull, Forbes Life, baby books, video games, and Jamba Juice. Kate works for a Whole Foods-like company called Round Earth.
Social drinking -- including one scene in which a woman who's purportedly pregnant sneaks a few swigs of hard liquor at a nightclub. Several jokes about recreational drug use.