For all of the bluster of one of the characters, the movie's overall message is heartwarming and affirming: A list filled with exotic adventures is fun, but the biggest task to check off before your time is up is staring life (or death) in the face and embracing its daily joys.
At one point, Cole and Chambers scream at each other on a sidewalk. A married couple also argues (not much screaming, but there's tension).
A flight attendant leaves an airplane washroom looking unkempt and fastening the buttons of her blouse; a man leaves the same washroom soon after (shenanigans are implied). A woman propositions a married man (he turns her down). Some semi-crass discussion of sex. A husband and wife embrace tenderly and reminisce about the first time they got together. One entry on the list is "to kiss the most beautiful woman in the room."
Everything from "goddammit" to "s--tty" to "f--king" (though the "F" word is used sparingly). One character gives another the finger.
Numerous raves for the kopi luwak, Indonesian coffee known to be the most expensive on earth. Signage for Cole's hospital, Reed Hill. A glimpse of a NYC taxi logo. One character loves to watch Jeopardy.
Drinking, Drugs & Smoking
Some drinking in social situations (restaurants, etc).