The movie has a sweetly positive messages about loyalty, determination, and teamwork. Characters who resist others' affection eventually learn to embrace it, and Bolt discovers that being loved is much more important than having super powers.
The peril is mostly in the TV show within the movie. After an early sequence (which could be intense for younger or more sensitive kids) it's made clear that the violence is manufactured, since the audience (unlike Bolt) sees the crew setting off explosions, catching stuntmen, etc. In the "real" world, there are cartoonish pratfalls and slapsticky violence, but nothing too disturbing -- until a tense, scary fire during the movie's climax that puts a central character in danger.
A couple of mild insults (like "stupid") among the animals.
Featured brands include The New Yorker, Tiger Beat, U-Haul, The Tonight Show (but not with a recognizable host), and several Las Vegas hotels, like the Bellagio; New York, New York; Bally's; and Caesar's Palace.