Male characters -- including Molly's father -- are uniformly immature and annoying: they lie, say cruel things, and engage in more than one "stinky" bathroom joke.
Positive Role Models & Representations
Fall on skateboarding ramp (Carl left with bruised lip); neighbor kid beat up by bullies; reference to "whacking" (Carl and Dupree like to watch The Sopranos); Carl punches his car in anger; Carl attacks Dupree (who ends up with a neck brace and bruised face); TV room burns, leaving everyone charred-looking; security guard chases Dupree through office building (throwing objects, crashing through walls, breaking doors).
Masturbation jokes (verbal and visual); discussions of vasectomies (including diagram of erect penis); we see Dupree's naked butt while he's asleep; references to Dupree's sexual activities (with butter and a "Mormon librarian" who turns out to be "a real slut"); several references to Carl's "Asian porn" collection; Carl imagines Molly and Dupree tongue-kissing.
Pushing PG-13 edge, with one f-word, several uses of s--t, and frequent uses of other obscenities.
Mentions of Starbucks, HBO, ESPN, Twinkies.
Ease of Play
Drinking; drinking games; brief cigar and cigarette smoking, mention of "weed," though we don't see anyone smoke it.