The plot is pretty much an album of calculated, anti-social acts, from pointless brawls and hazing to impersonating leukemia victims and organized vandalism sprees, all explained as rebellion against a desolate consumer society.

As the title implies, frequent fighting between men, under the pretense of reclaiming their masculinity and getting in touch with the primal in a sterile consumer society. Faces beaten and bruised, including one man's face beaten until pulpy and covered in blood. Members of the "fight club" are told to start a fight with a total stranger in public. Threats of and actual suicide by gun to mouth. Car crash after character stops steering and allows the car to careen into oncoming traffic before crashing into a ditch. Acts of urban vandalism result in the death of one of the characters, shot by a police officer and shown bleeding out the back of his blown-out head. Graphic scene in which scalding acid is burned on character's hand as a test of strength as the character screams and writhes in intense pain. Character has visions of a plane crash. Skyscrapers detonated by planted explosives.

Two characters have loud and passionate sex. Nudity: Female breasts, male buttocks. The female character says she "hasn't been f--ked like that since grade school." Much talk of the breasts that grew on a male supporting character because of hormone treatment. While working as a projectionist in a movie theater, one of the characters splices in frames of pornography into family entertainment, one frame shots of penises; this is done in the actual movie at the very end. Reference to sex toys.

After sex, a female character says she has "not been f---ked like that since grade school." "S--thole." F-word used several times.

Addresses and satirizes materialism and commercialism, and how consumer culture is, for many Americans, linked to self esteem. References to Starbucks. One of the characters orders from an Ikea catalog. Characters drink Busch beer.

Vodka and beer drinking. Cigarette smoking. Scenes in bars. While threatening suicide, a woman talks of being high on Xanax.