The series paints an unflattering picture of the political system as a whole -- and the vice president's role in particular -- poking fun at closed-door deals designed to further careers rather than effect positive change and making light of all-too-familiar issues like sexual relationships between public servants and interns in particular. There's also some politically incorrect name-calling like "retard" and "freak." The casting of a woman in a powerful role is a plus, but since the show takes jabs at her failures in that role as its main source of laughs, it's somewhat counterproductive.
More referential than visual. There's mention of extramarital affairs, implications of using a career position to solicit sex from interns, and references to erections.
Frequent, comedic versions of "f--k" ("f--ktard," "pencil-f--ked," and plenty more), as well as "bitch," "t-t," "s--t," "d--k," "piss," and "God almighty."
Nothing stands out, but brand names like Dell, BlackBerry, and Wikipedia pop up in the context of the dialogue.