The show is a parody of medical dramas/soap operas like Grey's Anatomy; as such, it embraces and amps up every cliche in the genre's playbook, from angst-filled relationships to professional conflicts. Every situation is pushed over the top for maximum laughs, and no one is off limits for parodying, from religious groups (for instance, characters routinely refer to each other's religion, calling someone a "Jew") to people with disabilities.
One doctor has an intentionally creepy look, regularly appearing in full clown makeup and wearing surgical scrubs that seem to be splattered with blood.
Frequent sexual references. Some onscreen, clothed coupling that's played for laughs -- such as people locked in a long, intense make-out session in the middle of a crowded room, or two women who seem just about to start fooling around until they're interrupted.
Some swearing, including "butt," "ass," "bitch," and "son of a bitch." Other words are bleeped, and one character flashes the middle finger.