There's no real "message" ... other than the Internet is a pretty wacky place. The series also reinforces the concept that doing something gross, stupid, or vulgar in front of a camera can net you 15 minutes of fame. The show also tends to glorify dangerous stunts and scatological humor. Tosh's humor sometimes pokes fun specifically at women or "foreigners."
Some videos show accidents with painful consequences.
No nudity, but frequent references to sex. Some clips show women in bathing suits and lingerie, animals having sex, and blurred-out pornography (including graphic sexual sounds).
Some swearing, including "ass" and "douche." Plus muted curse words.
Drinking, Drugs & Smoking
Tosh sometimes suggests that the people in the show's featured video clips are under the influence of something, and uses words like "stoned" and "buzzed."