Don't look for any positive take-aways here; the show revels in its hyper-violent, sexualized content and doesn't make any attempt to convey anything remotely positive.
Characters routinely engage in savage, gruesome fights using a variety of weapons and sometimes just their bare hands. Heads, arms, and legs are pulled off; people are impaled, cut in two, and worse; and there's plenty of blood and guts. Some fights occur in anger with little provocation, while others are staged for entertainment. The show seems to revel in its ability to shock -- all of this is animated, but it's still quite gruesome.
Some animated nudity, and plenty of sexually charged situations and imagery. There are almost no women in the jail's world, and several scenes suggest homosexual behavior using stereotypical images -- including violent jailhouse encounters and group sex. One guard character appears to be either a man in drag or a transsexual; the show doesn't specify, but it does base some plotlines on Alice's mysterious sexuality.
Few actual swear words, though there are plenty of sexually suggestive phrases.
Drinking, Drugs & Smoking
A fair amount of drinking, sometimes to excess, that leads to impulsive behavior. One character, a recovering alcoholic, is mocked for trying to abstain and finally falls off the wagon.