There is some positive messaging in the portrayal of the officers who attempt to solve the show's crimes, and in their applying specialized knowledge to the investigative process.
Crime scenes show blood, crimes themselves can be very violent (disemboweling, tongues cut out), and autopsies can be graphic. Some plots involve serial killers.
Plenty of sexually-tinged banter and innuendo. While there is discussion of romantic relationships, very little of it is sexual, and what does veer in that direction is tame by prime-time standards.
Some swearing ("ass," "bitch," "damn") and some sexual language play: "pussy ... cat."
No real product placement, though fake Starbucks and Big Gulp cups are visible.
Main characters do not smoke, drink obviously, or use drugs. Use may appear in some subplots.