While there's a strong sense of friendship and loyalty among the guys, there's also a lot of entitlement and cockiness within their dynamic. Women are more objects than full characters. Some might find a critique of Hollywood amid the plots.
Mostly verbal sparring, with occasional fist fights.
Young, single, on-the-prowl guys are on the loose in Hollywood, along with their female counterparts. A girlfriend skinny dips in front of all of the characters, there are one-night stands galore, a character cheats on his girlfriend out of spite, characters make lewd comments about women.
One word: Explosive. Nearly every curse word under the sun gets full use.
More materialism than outright commericalism/product placement. Characters go shopping on Rodeo Drive and attend parties that are dripping in swag. Name the hot new product and it's most likely name-dropped here.
Drinking, Drugs & Smoking
Smoking and drinking seem as common as breathing. Characters smoke weed in every episode.