The show's edgy, non-politically correct humor includes jokes about disabilities, the overweight, and affirmative action. There's one African-American character (who is the smartest on the show) and one or two females.
Frequent cartoon violence, though more is referenced than shown -- such as a description of an attack victim as having no more face.
References to sex are often oblique and include chauvinistic jokes and borderline sexual harrassment.
Some profanity, including plenty of "hell" and "damn" and the occasional "ass."
Occasional episodes involve strange drugs or drug-like effects.