Plenty of petty behavior on display -- not to mention some stereotyping and other iffy choices -- but the show also emphasizes the importance of unconditional friendship. Karen, Jack, Will, and Grace are all dear friends who are there for each other when it counts. They do mock and tease each other incessantly, though. At various times, Will calls Jack "ridiculous" while Jack calls him "a sad middle-aged lady." Other jokes target sensitive/mature topics (sex, politics) and sometimes "punch down": gags about older people, women, unattractive people -- like one line in which Madonna is said to have "the face of Baby Jane and the body of Iggy Pop."
Some pratfalls and slapstick humor.
Frequent jokes about sex, casual sex, body parts, different types of sex. A sampling: "Grindr has gotten so skanky, I feel like I could get finger herpes just from scrolling." "Everybody knows the Secret Service is all gay." "Did you get serviced?" While brandishing a syringe full of Botox: "Let's turn those old man balls into little white marbles." Expect same-sex and opposite-sex kissing, dating, "hooking up," and lots of talk about all of this.
Words like "bitch" and "ass" are commonplace. Infrequent cursing and language includes "damn," "hell," "fart," "c--k," "balls."
Karen in particular enjoys the finer things in life, from the best clothes to the best champagne -- many brands are mentioned. All the main cast are financially well-off.
Drinking, Drugs & Smoking
Prescription drug abuse is portrayed as humorous; one of the supporting characters is always drinking or taking pills.