The show uses parody and gross-out humor to address semi-serious issues -- war, political chicanery, sexism, classism. Characters are frequently stereotyped, but sometimes in subversive and pointed ways: a black character is called "token." A disabled character named Timmy is a minor character and accepted member of a group of young friends in later seasons (instead of being a one-joke character in earlier seasons), but also says things like "tard."

Over-the-top cartoon violence is more gross than scary. The same character dies in almost every one of the early episode, often brutally. Later episodes drop that joke, but still mock death and violence in absurd ways.

Sexual innuendo frequent; endless jokes about hermaphrodites, homosexuality, promiscuity, and pedophilia. Lots of bare butts.

Frequent cursing, often from young characters. "Hell," "damn," "crap," and other vulgar language is not bleeped when aired, "s--t" and "f--k" are bleeped. Language is not bleeped online. Racist, homophobic, and antireligious slurs frequent.

Episodes parody products such as iPads and other brands, including Chipotle and Starbucks. Real celebs such as Beyonce, Taylor Swift, and Elon Musk are mocked, or appear on the show as characters.

Drug use (illegal and prescription) and alcohol are sometimes portrayed in a negative light.