The series takes a comedic look at blue-collar family life and the realistic ups and downs that come with raising kids, dealing with in-laws, work issues, money struggles, divorce, etc. Newer episodes feature much of the same, but in a more contemporary context.
Yelling is frequent during arguments. Roseanne's abusive childhood is sometimes referenced, and a few episodes specifically deal with domestic violence (bruises and a black eye visible). Bullying is a theme in some episodes.
Moderately graphic talk about sexual issues is common, ranging from tongue-kissing, teen sex, and going on birth control to using men to get pregnant. One episode features a well-known porn star. Pregnancy and childbirth are also addressed in various episodes and seasons.
Adults and teens alike use strong language like "bitch," "damn," "ass," and "crap." Closing scenes sometimes feature bleeped curses as a joke.
References to Cool Whip, Jell-O, Milky Ways, and other products.
Drinking, Drugs & Smoking
Adults often kick back with a beer (or six) after work or in social gatherings, and there's some underage drinking (with negative consequences). Early seasons feature Roseanne and other characters smoking cigarettes; occasionally cigars are smoked during poker games. One episode features adults smoking pot. Later episodes features an adult character fighting opioid addiction.